Focal proliferative nephritis

Focal proliferative nephritis is a type of glomerulonephritis seen in 20% to 35% of cases of SLE, classified as type III SLE. As the name suggests, lesions are visualized in only portions of fewer than half the glomeruli. Typically, one or two foci within an otherwise normal glomerulus show swelling and proliferation of endothelial and mesangial cells, infiltration by neutrophils, and/or fibrinoid deposits with capillary thrombi. Focal glomerulonephritis is usually associated with only mild microscopic hematuria and proteinuria; a transition to a more diffuse form of renal involvement is associated with more severe disease.^[1]

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